General Cell Lines and Cell Cultures
Biochain Institute Inc Frozen Tissue Section - Alzheimer's Disease: Brain: Parietal Lobe, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Biochain Institute Inc Colon Tumor Tissue Array - 64 Different Colon tumors. Plus positive control and negative control, 5 slides/PK
BioChain's tissue arrays or tissue microarrays (TMAs) are a useful tool in biomarker research and drug target validation. It consists of paraffin blocks that are assembled in array fashion to allow multiplex histological analysis. BioChain's TMAs provide a valuable tool for analysis of protein, RNA, or DNA molecules in oncology, both the malignant and metastatic markers. TMAs can also be constructed with tissues from other diseases and species.
Genscript Corporation CHO-K1/cyno BDCA2 Stable Cell
BDCA-2 is a novel type II C-type lectin which shows 50 7% sequence identity at the amino acid level to its putative murine ortholog the murine dendritic cell associated C-type lectin 2 In addition to its antigen capturing function BDCA-2 can mediate potent inhibition of induction of IFN- / expression in PDCs Production of IFN- / in response to several different types of viruses bacteria CpG-DNA dsRNA and SLE serum is by far the most prominent feature of PDCs
Eurofins Discoverx PathHunter CHO-K1 TACR3 β-Arrestin Cell Line, 2 vials. (93-0501C2)
The PathHunter TACR3 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. substance P, senkitide) based activation of TACR3 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged TACR3 and EA-tagged β-Arrestin-2. Activation of TACR3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx RBL-2H3 MRGPRX1 Gq Cell Line, 2 vials. (95-1019C11)
The MRGPRX1 Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. BAM (8-22)) based activation of MRGPRX1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses MRGPRX1, a naturally Gq coupled GPCR. Upon activation of MRGPRX1, the resulting calcium activity can be fluorescently assayed using the Calcium No WashPLUS Detection Kit. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Frozen Tissue Section Panel - Rat Normal Tissue, Multi-tissue III, 5 slides/PK
BioChain's Sprague Dawley or Wistar rat normal multiple frozen tissue panels are designed for studying tissue specific cellular localization of genes or proteins of interest in different rat tissues. 8 different frozen tissues are mounted on positively charged glass slides. Total RNA Northern Blots are available in the identical format, and cDNA from those tissues may also be available for PCR detection.
Eurofins Discoverx PathHunter CHO-K1 PTGIR β-Arrestin Cell Line, 2 vials. (93-0305C2)
The PathHunter PTGIR cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin I2, beraprost) based activation of PTGIR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTGIR and EA-tagged β-Arrestin-2. Activation of PTGIR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx ChemiBrite DP Prostanoid Receptor Stable Cell Line, 2 vials. (HTS091L)
The ChemiBrite DP Prostanoid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin D2) based activation of PTGDR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGDR alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGDR, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Sigma Aldrich Fine Chemicals Biosciences MDR1 Knockout Caco-2 Cells one vial | 1VL
MDR1 Knockout Caco-2 Cells one vial | 1VL
Amsbio LLC Lyophilized exosomes from Urine of Healthy donors
Lyophilized exosomes from Urine of Healthy donors
Abcam CGP 7930, Positive allosteric modulator of GABAB receptors, 50MG
MW 292.5 Da, Purity >98%. Positive GABAB receptor allosteric modulator (EC50 values are 5.37 and 4.60 μM, respectively). Increases receptor agonist affinity and signal transduction efficacy. Also shown to potentiate receptor response to baclofen (ab120325).
The product is subject to the following: Abcam Restricted Use Statement
Biochain Institute Inc Matched Pair - Frozen Tissue Section - Human Primary and Matched Metastatic Tumor (PM): Rectum, 5 x2 slides /PK
BioChain's tissue products are based on the sample repository network established following the ethical standard and IRB-approved procedures. During the collection, the excised tissues are immediately put into liquid nitrogen and then identified by a board-licensed pathologist. Patient demographic and disease related history data are available. Human frozen tissue section matched pair products include: Primary Pair (PP), Primary and Metastatic Pair (PM). PP consists of frozen tissue sections of primary tumor and its adjacent normal tissue; PM consists of frozen tissue sections of primary tumor and corresponding metastatic tumor. Frozen tissue sections in each pair are prepared from the same donor. This product line is ideal for localization of tumor-specific genes and tumor metastatic genes.
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Blood Vessel: Artery, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx Ready-to-Assay µ Opioid Receptor Frozen Cells, 2 Vials of Cells. (HTS101RTA)
The Ready-to-Assay µ Opioid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. opioids) based activation of OPRM1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses OPRM1 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of OPRM1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.